| Date | Location | Result | |
| Nov 12, 2010 | Richmond, Va. | William and Mary 3, VCU 2 (18-25,25-23,20-25,25-20,15-11) | Box score |
| Nov 6, 2010 | Williamsburg, Va. | Delaware 3, William and Mary 0 (25-22,25-22,25-13) | Box score |
| Nov 5, 2010 | Williamsburg, Va. | Towson 3, William and Mary 0 (25-20,25-22,25-23) | Box score |
| Oct 30, 2010 | Boston, Mass. | Northeastern 3, William and Mary 1 (25-13,11-25,25-20,25-21) | Box score |
| Oct 29, 2010 | Hempstead, N.Y. | William and Mary 3, Hofstra 0 (25-18,25-16,26-24) | Box score |
| Oct 23, 2010 | Williamsburg, Va. | Georgia State 3, William and Mary 2 (29-27,25-18,21-25,19-25,18-16) | Box score |
| Oct 22, 2010 | Williamsburg, Va. | William and Mary 3, UNC Wilmington 0 (25-16,25-16,25-23) | Box score |
| Oct 16, 2010 | Harrisonburg, Va. | James Madison 3, William and Mary 2 (23-25,22-25,25-21,32-30,15-12) | Box score |
| Oct 15, 2010 | Fairfax, Va. | George Mason 3, William and Mary 0 (25-20,25-16,25-12) | Box score |
| Oct 9, 2010 | Newark, Del. | Delaware 3, William and Mary 0 (25-18,25-19,25-14) | Box score |
| Oct 8, 2010 | Towson, Md. | William and Mary 3, Towson 2 (20-25,25-18,25-22,21-25,15-4) | Box score |
| Oct 2, 2010 | Williamsburg, Va. | VCU 3, William and Mary 0 (25-21,25-20,25-17) | Box score |
| Sep 25, 2010 | Williamsburg, Va. | Northeastern 3, William and Mary 1 (25-20,23-25,25-23,25-18) | Box score |
| Sep 24, 2010 | Williamsburg, Va. | William and Mary 3, Hofstra 1 (25-21,21-25,25-17,25-23) | Box score |
| Sep 18, 2010 | Villanova, Pa. | Villanova 3, William and Mary 0 (25-19,25-21,25-15) | Box score |
| Sep 18, 2010 | Villanova, Pa. | William and Mary 3, Maryland 2 (21-25,25-21,20-25,25-23,15-10) | Box score |
| Sep 17, 2010 | Villanova, Pa. | William and Mary 3, Long Island 0 (26-24,25-23,25-13) | Box score |
| Sep 11, 2010 | Charlotte, N.C. | William and Mary 3, North Carolina A&T 0 (25-15,25-11,25-14) | Box score |
| Sep 11, 2010 | Charlotte, N.C. | Alabama A&M 3, William and Mary 0 (25-21,25-18,25-20) | Box score |
| Sep 10, 2010 | Charlotte, N.C. | Charlotte 3, William and Mary 0 (25-23,25-23,25-22) | Box score |
| Sep 4, 2010 | Williamsburg, Va. | American 3, William and Mary 0 (25-19,25-20,25-19) | Box score |
| Sep 4, 2010 | Williamsburg, Va. | William and Mary 3, Hampton 0 (25-9,25-16,25-13) | Box score |
| Sep 3, 2010 | Williamsburg, Va. | William and Mary 3, Campbell 1 (27-25,19-25,25-20,25-18) | Box score |
| Aug 28, 2010 | Williamsburg, Va. | William and Mary 3, Winthrop 2 (25-23,25-18,25-27,18-25,15-13) | Box score |
| Aug 27, 2010 | Williamsburg, Va. | Wisconsin 3, William and Mary 0 (25-18,25-15,25-17) | Box score |
| Aug 27, 2010 | Williamsburg, Va. | Seton Hall 3, William and Mary 2 (25-27,22-25,25-22,25-17,15-9) | Box score |