| Date | Location | Result | |
| Nov 18, 2000 | Harrisonburg, Va. | James Madison 3, William and Mary 0 (15-7,15-11,16-14) | Box score |
| Nov 11, 2000 | Williamsburg, Va. | William and Mary 3, UNC Wilmington 0 (15-5,15-9,15-4) | Box score |
| Nov 10, 2000 | Williamsburg, Va. | William and Mary 3, East Carolina 0 (15-6,15-6,15-8) | Box score |
| Nov 7, 2000 | Richmond, Va. | Va. Commonwealth 3, William and Mary 2 (10-15,15-12,15-17,15-10,15-12) | Box score |
| Nov 3, 2000 | Williamsburg, Va. | James Madison 3, William and Mary 1 (15-13,11-15,16-14,15-11) | Box score |
| Oct 30, 2000 | Norfolk, Va. | William and Mary 3, Norfolk State 0 (15-1,15-0,15-1) | Box score |
| Oct 28, 2000 | Greenville, N.C. | East Carolina 3, William and Mary 1 (15-7,13-15,15-8,15-10) | Box score |
| Oct 27, 2000 | Wilmington, N.C. | William and Mary 3, UNC Wilmington 0 (15-11,15-6,15-6) | Box score |
| Oct 21, 2000 | Williamsburg, Va. | William and Mary 3, George Mason 1 (15-11,15-12,8-15,15-7) | Box score |
| Oct 20, 2000 | Williamsburg, Va. | American 3, William and Mary 0 (15-9,15-6,15-12) | Box score |
| Oct 16, 2000 | San Diego, Calif. | San Diego State 3, William and Mary 0 (15-9,15-14,16-14) | Box score |
| Oct 15, 2000 | Irvine, Calif. | William and Mary 3, UC Irvine 0 (15-13,15-13,15-12) | Box score |
| Oct 13, 2000 | Berkeley, Calif. | California 3, William and Mary 1 (16-14,13-15,15-11,15-7) | Box score |
| Oct 6, 2000 | Harrisonburg, Va. | James Madison 3, William and Mary 2 (15-12,15-9,10-15,10-15,15-12) | Box score |
| Oct 3, 2000 | Hampton, Va. | William and Mary 3, Hampton 0 (15-5,15-4,15-4) | Box score |
| Sep 30, 2000 | Williamsburg, Va. | William and Mary 3, Virginia Tech 0 (15-3,16-14,15-13) | Box score |
| Sep 30, 2000 | Williamsburg, Va. | William and Mary 3, Md.-Baltimore County 1 (15-7,14-16,15-8,15-12) | Box score |
| Sep 29, 2000 | Williamsburg, Va. | William and Mary 3, Va. Commonwealth 1 (15-5,12-15,15-5,16-14) | Box score |
| Sep 23, 2000 | Washington, D.C. | American 3, William and Mary 0 (15-5,15-12,15-12) | Box score |
| Sep 22, 2000 | Fairfax, Va. | William and Mary 3, George Mason 1 (15-10,13-15,15-4,15-10) | Box score |
| Sep 16, 2000 | College Park, Md. | William and Mary 3, Morgan State 0 (15-3,15-3,15-1) | Box score |
| Sep 16, 2000 | College Park, Md. | East Carolina 3, William and Mary 1 (15-3,8-15,15-5,15-7) | Box score |
| Sep 15, 2000 | College Park, Md. | Maryland 3, William and Mary 0 (15-6,15-12,15-13) | Box score |
| Sep 9, 2000 | Williamsburg, Va. | William and Mary 3, Delaware 0 (15-9,15-2,15-6) | Box score |
| Sep 9, 2000 | Williamsburg, Va. | William and Mary 3, Loyola (Md.) 0 (15-8,15-8,15-10) | Box score |
| Sep 8, 2000 | Williamsburg, Va. | William and Mary 3, Pennsylvania 0 (15-11,15-6,15-10) | Box score |
| Sep 2, 2000 | Charlottesville, Va. | Georgetown 3, William and Mary 1 (15-10,15-10,16-18,15-3) | Box score |
| Sep 1, 2000 | Charlottesville, Va. | Kentucky 3, William and Mary 2 (15-10,9-15,16-18,15-13,15-8) | Box score |
| Sep 1, 2000 | Charlottesville, Va. | Virginia 3, William and Mary 1 (16-14,15-5,10-15,15-6) | Box score |